IBAM   22618
INSTITUTO DE BIOLOGIA AGRICOLA DE MENDOZA
Unidad Ejecutora - UE
artículos
Título:
POTENTIAL PROTECTIVE ROLE OF NITRIC OXIDE AND HSP70 LINKED TO FUNCTIONAL FOODS IN THE ATHEROSCLEROSIS
Autor/es:
WALTER MANUCHA; ALEJANDRA B. CAMARGO
Revista:
Clínica e Investigación en Arteriosclerosis
Editorial:
Elsevier
Referencias:
Lugar: Barcelona ; Año: 2016
Resumen:
Atherosclerosis, one of the main pathologic entities considered epidemicand a worldwide public health problem, is currently under constant reviewas regards its basic determining mechanisms and therapeuticpossibilities. In this regard, all patients afflicted with the diseaseexhibit mitochondrial dysfunction, oxidative stress and inflammation.Interestingly, nitric oxide -a known vasoactive messenger gas- has beenclosely related to the inflammatory, oxidative and mitochondrialdysfunctional process that characterizes atherosclerosis. In addition, ithas recently been demonstrated that alterations in the bioavailability ofnitric oxide would induce the expression of heat shock proteins. Thisagrees with the use of functional foods as a strategy to prevent bothvascular aging and the development of atherosclerosis. Finally, a greaterknowledge regarding the mechanisms implied in the development ofatherosclerosis will enable proposing new and possible hygiene, healthand therapeutic interventions.