INVESTIGADORES
RABINOVICH Gabriel Adrian
capítulos de libros
Título:
IMMUNOGLYCOBIOLOGY: AN OVERVIEW
Autor/es:
BLIDNER, ADA; ILARREGUI, JUAN; RABINOVICH, GABRIEL
Libro:
GLYCOSCIENCE: BIOLOGY AND MEDICINE
Editorial:
Springer
Referencias:
Lugar: Tokyo; Año: 2014;
Resumen:
Although originally proposed as functional tuners capable of influencing signaling thresholds of immune cells, emerging evidence indicates a more central and hierarchical role of glycans and glycan-binding proteins as stimulators or inhibitors of innate and adaptive immunity. An increasing number of studies reveal the relevance of glycan-containing information in host-pathogen recognition and the control of immune cell homeostasis, inflammation and tumor immunity. In this chapter, we summarize general concepts of glycoimmunology and illustrate selected examples of the contribution of glycans and glycan-binding proteins (C-type lectins, siglecs, and galectins) to innate and adaptive immune responses in physiologic and pathologic settings.
