The paradoxical roles of inflammation during PD-1 blockade in cancer

MARCELO HILL; MERCEDES SOFIA; SOFIA RUSSO; M. ROMINA GIROTTI; GABRIEL A RABINOVICH

TRENDS IN IMMUNOLOGY

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2020

1471-4906

Recent studies have reported paradoxical roles of inflammation in tumor immunity triggered by PD-1 checkpoint antibody (Ab) blockade. Here we elaborate on this controversy and propose a new perspective that might help understand this paradox. Since inflammatory cytokines and PD-1 blockade are known to target different subsets of exhausted CD8+ T cells, we propose that the timing at which anti-PD-1 Ab therapy and cytokine modulation occur might determine the fate of exhausted CD8+ T cells and, perhaps, the clinical outcome of immunotherapeutic modalities.