AP1-DEPENDENT GALECTIN-1 EXPRESSION DELINEATES CLASSIC HODGKIN AND ANAPLASTIC LARGE CELL LYMPHOMAS FROM OTHER LYMPHOID MALIGNANCIES WITH SHARED MOLECULAR FEATURES

SCOTT J RODIG; JIN OUYANG; PRZEMYSLAW JUSZCZYNSKI; TREEVE CURRIE; KENNETH LAW; DONNA S. NEUBERG; GABRIEL A. RABINOVICH; MARGARET A. SHIPP; JEFFERY L. KUTOK

CLINICAL CANCER RESEARCH

AACR Journals

Año: 2008 vol. 14 p. 3338 - 3344

1078-0432

Galectin-1 is an immunomodulatory glycan-binding protein regulated by an AP1-dependent enhancer in Hodgkin Reed-Sternberg cells. We recently found that Reed Sternberg cell Gal-1 promotes the immunosuppressive T helper2/ T-regulatory cell-skewed microenvironment in classic Hodgkin lymphoma (cHL). We sought to investigate whether the the coordinate expression of activated AP1 pathway components and Gal-1 serves as a diagnostic signature of cHL. In addition, because there are common signaling and survival pahtways in cHL and additional non-Hodgkin lymphomas, we also evaluated whether the AP1/Gal1 signature is shared by other molecularly or morphologically related lymhomas. Our findings establish a functional AP1 signature that incluses Gal-1 expression in cHL and ALCL, and suggests a common mechanmism for tumor immunotolerance in these diseases. In addition, the combination of Gal1 and c-Jun serve as diagnostic biomarkers that delineate cHL and ALCL from other lymphomas with shared morphologic and/or molecular features.