INVESTIGADORES
RABINOVICH Gabriel Adrian
artículos
Título:
MAST CELLS ARE CRITICAL FOR IMPLANTATION AND MAINTENANCE OF PREGNANCY
Autor/es:
WOIDACKI K; POPOVIC M; METZ M; SCHUMACHER A; LINZKE N; TELES A; POIRIER F; FEST S; JENSEN F; RABINOVICH GA*; MAURER M*; ZENCLUSSEN AC* (*COMPARTEN ÚLTIMA AUTORÍA)
Revista:
CELL DEATH AND DISEASE
Editorial:
NATURE PUBLISHING GROUP
Referencias:
Lugar: Londres; Año: 2013 vol. 17 p. 462 - 468
ISSN:
2041-4889
Resumen:
Abstract In spite of their traditional role in allergic disorders and innate immunity, mast cells (MCs)have emerged as versatile modulators of a variety of physiologic and pathologic processes. Here we show that MCs are critical for pregnancy success. Uterine MCs presented a unique phenotype, accumulated during receptivity and expanded upon pregnancy establishment.MCs displayed a dual role in pregnancy either by facilitating implantation or by promoting placentation and fetal growth. Genetically MC-deficient KitW-sh/W-sh mice exhibited severely impaired implantation, which could be completely rescued by systemic or local transfer of wild-type bone marrow-derived MCs. MCs favored normal implantation, induced optimal spiral artery remodeling and promoted the expression of MC proteases, transforming growth factor-β and connective tissue growth factor. Besides, MCs contributed to placentation and fetal survival through secretion of the glycan-binding protein galectin-1. Our data unveil unrecognized roles for MCs at the feto-maternal interface with critical implications in reproductive medicine.