GLYCOBIOLOGY OF CELL DEATH: WHEN GLYCANS AND LECTINS GOVERN CELL FATE

RACHEL LICHTENSTEIN; GABRIEL RABINOVICH

CELL DEATH AND DIFFERENTIATION

NATURE PUBLISHING GROUP

Lugar: Londres; Año: 2013 vol. 20 p. 976 - 986

1350-9047

Although one typically thinks of carbohydrates as associated with cell growth and viability, glycosylation also has an integral role in many processes leading to cell death. Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings.Cell Death and Differentiation advance online publication, 24 May 2013; doi:10.1038/cdd.2013.50