MEAT SPECIFIC IgG AND IgA ANTIBODIES COEXIST WITH IgE ANTIBODIES IN SERA FROM ALLERGIC PATIENTS: CLINICAL ASSOCIATION AND MODULATION BY EXCLSUION DIET

CALDERON TERESA; FERRERO MERCEDES; MARINO GUSTAVO; CÓRDOBA ANDRÉS; BELTRAMO DANTE; MUIÑO JUAN CARLOS; RABINOVICH GABRIEL; ROMERO MARTA

JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS

BIOLIFE SAS

Lugar: CHIETTI; Año: 2010 vol. 24 p. 251 - 261

0393-974X

IgE-mediated responses play a pivotal role in allergic patients with food intolerance. However, the association of food-specific IgG and IgA antibodies with the clinical outcome of allergic patients is still a matter of controversy. Here we investigated whether beef-specific IgG and IgA antibodies may coexist with beef-specific IgE antibodies in food allergic patients and examined their clinical relevance in different allergic settings. Beef-specific IgE, IgG and IgA antibodies were determined by solid-phase enzymoimmunoassay (ELISA) in a population of allergic patients (N=125) classified into patients with asthma, skin disease or gastrointestinal disorders, as well as in control subjects (N=80). IgE specific antibodies for citric fruits, tomato, cow’s milk, hen’s egg and wheat were also determined. Beef was the predominant allergenic food in the whole population, not only for IgE (57.6%; P