Hybrid formulations for the treatment of glaucoma and dry eye

HERRERO-VANRELL ROCIO; VICARIO-DE-LA-TORRE MARTA; ANDRES-GUERRERO VANESSA,; QUINTEROS DANIELA; PALMA SANTIAGO; ALLEMANDI DANIEL, ; BENITEZ-DEL CASTILLO JOSE MANUEL; MOLINA-MARTINEZ IRENE TERESA

Berlin

Simposio; International Symposium on Ocular Pharmacology and Therapeutics (ISOPT); 2015

ISOPT

Treatment of glaucoma is usually performed with continuous instillations of hypotensive eye drops. Despite the usefulness of topical route, chronic administration of antiglaucoma medications is usually associated with adverse reactions due to the drug or excipients included in the formulation. Among the excipients employed in eye drops, preservatives are the most related to surface alterations. Elimination of antimicrobial agents from the topical formulations is not always enough to avoid non desired effects and the ocular surface might be altered. The development of hybrid formulations including components able to improve the symptoms dry eye is an important challenge in the development of chronic antihypertensive therapies.