INVESTIGADORES
PALMA Santiago Daniel
congresos y reuniones científicas
Título:
Evaluation of rapidly disintegrating tablets based on solid dispersions
Autor/es:
CASTRO, SILVINA; ALLEMANDI DANIEL; PALMA SANTIAGO
Lugar:
Córdoba
Reunión:
Congreso; 1era Reunión Internacional de Ciencias Farmacéuticas; 2010
Institución organizadora:
Facultad de Ciencias Químicas - UNC
Resumen:
INTRODUCTION Solid dispersions (SDs) have been proposed as an alternative to improve the dissolution rate of low solubility drugs1. In previous studies, SDs containing albendazole (ABZ) and poloxamer188 (P188) were formulated. The dissolution profiles indicated that ABZ incorporated in SDs (as multiparticles) was rapidly released compared with free ABZ. The aim of the present study was to develop and evaluate rapidly disintegrating tablets (RDT) containing ABZ – P188 DSs. MATERIALS AND METHODS DSs were prepared by the melting method. Directly compressible rapidly disintegrating tablets using 200 mg of ABZ, 732 mg of LudiflashTM, 60mg of sodium crosscaramellose and 8mg of magnesium stearate were prepared at different compaction forces (250, 500 and 1000 mPa). Tablets containing only ABZ were used as controls. Powder flowability and tablet mechanical properties were measured. The dissolutions tests were performed using 0,1N HCl and Gastric Simulated Solution pH:1,2 (GSS) + Sodium Lauryl Sulfate (SLS) 0,25 % p/v3 as medium. RESULTS Table 1 shows the effect of compaction force on the hardness and disintegration time of the tablets. ABZ incorporated in SDs tablets was released faster than multiparticle systems. So, this formulation would be advantageous from a pharmaceutical point of view, compared to powdered solid dipersions. As might be expected, tablets containing ABZ without P 188 showed lower dissolution rate than those containing DSs. The presence of SLS improved drug dissolution. The surface tension of the medium and the wettability of the drug would be playing a central role in the dissolution of ABZ. (Table 2 and 3). CONCLUSIONS ABZ dissolution was improved when formulated in SDs. However, this property has to remain unaltered when these SDs have to be vehiculized in tablets. In this work, we developed a RDT by using a coproccesed granular excipient (LudiflashTM). The main characteristic of these tablets was its very fast disintegration which facilitated the inmediate exposure of powdered SDs to the dissolving medium. So, drug release was even faster. Besides, the deleterious effect of compaction force on disintegration time was practically negligible.