INVESTIGADORES
PALMA Santiago Daniel
artículos
Título:
Dissolution profiles of fenbendazole from binary solid dispersions: A mathematical approach
Autor/es:
MELIAN, MARÍA ELISA; BRIONES NIEVA, CINTIA ALEJANDRA; DOMÍNGUEZ, LAURA; GONZO, ELIO EMILIO; PALMA, SANTIAGO; BERMÚDEZ, JOSÉ MARÍA
Revista:
Therapeutic Delivery
Editorial:
Future Medicine Ltd.
Referencias:
Año: 2021 vol. 12 p. 597 - 610
ISSN:
2041-5990
Resumen:
Aim: Understanding a drug dissolution process from solid dispersions (SD) to develop formulations with predictable in vivo performance. Materials & methods: Dissolution data of fenbendazole released from the SDs and the control physical mixtures were analyzed using the Lumped mathematical model to estimate the parameters of pharmaceutical relevance. Results: The fit data obtained by Lumped model showed that all SDs have a unique dissolution profile with an error of ±4.1% and an initial release rate 500-times higher than the pure drug, without incidence of drug/polymer ratio or polymer type. Conclusion: The Lumped model helped to understand that the main factor influencing the fenbendazole release was the type formulation (SD or physical mixture), regardless of the type or amount of polymer used.