INVESTIGADORES
PALMA Santiago Daniel
artículos
Título:
Development and in vitro evaluation of solid dispersions as strategy to improve albendazole biopharmaceutical behavior
Autor/es:
SIMONAZZI, ANALÍA; CID, ALICIA GRACIELA; PAREDES, ALEJANDRO JAVIER; SCHOFS, LAUREANO; GONZO, ELIO EMILIO; PALMA, SANTIAGO DANIEL; BERMÚDEZ, JOSÉ MARÍA
Revista:
Therapeutic Delivery
Editorial:
Future Medicine Ltd.
Referencias:
Lugar: NY; Año: 2018 vol. 9 p. 623 - 638
ISSN:
2041-5990
Resumen:
Aim: Solid dispersions using Poloxamer 407 as carrier were developed to improve albendazole (ABZ) solubility and dissolution profiles. Methods: ABZ/poloxamer solid dispersions were prepared, and dissolution profiles were mathematically modeled and compared with physical mixtures, pharmaceutical ABZ and a commercial formulation. Results: Poloxamer 407 increased exponentially ABZ solubility, in about 400% when 95% w/w of polymer compared with its absence. Solid dispersions initial dissolution rate was three to 20-fold higher than physical mixtures, the drug and the commercial formulation. All the solid dispersions required less than 2.2 min to reach an 80% of ABZ dissolution, while the commercial formulation needed around 40 min. Conclusion: Solid dispersions improved ABZ solubility and dissolution rate, which could result in a faster absorption and an increased bioavailability.