INVESTIGADORES
PALMA Santiago Daniel
artículos
Título:
Nanostructures form alkyl Vitamin C derivatives (ASCn): properties and potential platform for drug delivery
Autor/es:
SANTIAGO DANIEL PALMA,; HILARIO MANZO, RUBEN; LO NOSTRO, PIERANDREA; ALBERTO ALLEMANDI, DANIEL
Revista:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Referencias:
Año: 2007 vol. 345 p. 26 - 34
ISSN:
0378-5173
Resumen:
Alkyl vitamin C derivatives (ASCn)
combine in their structure a lipophylic and a hydrophilic moiety and exhibit
properties of typical surfactant molecules. Self assembly properties of ASCn
depend on the length of n-alkyl fatty chain. ASCn start to aggregate at
temperatures (CMT, Krafft point) in which the solubility reaches the critical
micellar concentration (CMC). Above this temperature, ASCn can aggregate in
micelles or gel phase, depending of alkyl side chain. Upon cooling, for less
soluble derivatives (ASC12, ASC14 and ASC16) liquid-crystal structures named
coagels are obtained. They are
able to solubilized insoluble and
unstable drugs, protect then from any possible aggressive environment and
promote their permeation through skin. Besides, the rheological properties of
the coagels would be adequate for topical administration of pharmaceutical.
These systems possess very interesting properties making ASCn coagels promising
pharmaceutical platforms for drug delivery. Results from investigations about
all these properties are described and analyzed. Also, the perspectives of
these systems as drug delivery systems are discussed.