INVESTIGADORES
PALMA Santiago Daniel
artículos
Título:
Comparative plasma exposure of albendazole after administration of rapid disintegrating tablets in dogs
Autor/es:
CASTRO S; DIB A; SUAREZ G; ALLEMANDI D,; LANUSSE, C; SANCHEZ BRUNI S; PALMA S. D
Revista:
Biomed Research International
Editorial:
Hindawi
Referencias:
Lugar: New York; Año: 2013 vol. 203 p. 1 - 7
ISSN:
2314-6133
Resumen:
Th emai nobjective so fthi sstud ywer e(a )t oevaluat ethein vitro performance of the rapid disintegration tablets as a way to improvethesoliddispersionsand(b)tostudytheinvivopharmacokineticsofthealbendazolemodifiedformulationindogs.Rapid disintegration of tablets seems to be a key factor for efficien cy ofsol iddispersio nswi threga rd toimproveme nt oft healbendazole bioavailability. Thein vivo assays performed on dogs showed a marked increase in drug plasma exposure when albendazole was given in solid dispersions incorporated into rapid disintegration tablets compared with conventional solid dosage form.