INVESTIGADORES
PALMA Santiago Daniel
artículos
Título:
Solubilization of hydrophobic drugs in Octanoyl-6-O-Ascorbic Acid micellar dispersions
Autor/es:
SANTIAGO DANIEL PALMA; HILARIO MANZO, RUBEN; ALBERTO ALLEMANDI, DANIEL; LAURA FRATONI,; LO NOSTRO, PIERANDREA
Revista:
Journal of Pharmaceutical Sciences
Referencias:
Año: 2002 vol. 91 p. 1810 - 1816
ISSN:
0022-3549
Resumen:
Alkanoyl-6-O-ascorbic acid esters are easily obtained from vitamin C, and
produce self-assembled aggregates in water solutions, with an inner hydrophobic pool
surrounded by an external hydrophilic shell. Compared to ascorbic acid, their solubility
in oils and fats is greatly enhanced, while the peculiar antioxidant activity is retained in
the polar head groups of such surfactants. In virtue of their amphiphilic nature, ascorbic
acid-based supramolecular systems can dissolve relevant amounts of hydrophobic,
poorly water soluble chemicals such as drugs, vitamins, and so on, and at the same time
they provide a suitable shield against oxidative deterioration of valuable materials. In
this article we report our study on the self-assembling properties of octanoyl-6-Oascorbic
acid in water, and on the solubilization of some lipophilic molecules in its
dispersions