INVESTIGADORES
PALMA Santiago Daniel
artículos
Título:
Dry Plants Extracts Loaded on Fumed Silica for Direct Compression: Preformulation and Formulation
Autor/es:
SANTIAGO DANIEL PALMA; HILARIO MANZO, RUBEN; ALBERTO ALLEMANDI, DANIEL
Revista:
Pharmaceutical Development And Technology
Referencias:
Lugar: -; Año: 1999 vol. 4 p. 523 - 530
Resumen:
This paper describes the development of a method to load fumed silica with vegetal material (solid
residue) from a liquid extract to obtain a solid loaded silica product (LSP) with satisfactory flow
properties and compressibility to be processed by direct-compression technology. Extracts of Melissa
officinalis L. (M.o.), Cardus marianus L. (C.m.), and Peumus boldus L. (P.b.) were used to load
silica support. The release of boldine from LSP (P.b.) reached 100% in HCl 0.1 N solution and only
approximately 70% in water. Some physicalmechanical properties of LSP (M.o. and C.m.) alone
and LSPexcipient mixtures were determined. The densities (bulk and tap) of LSP were higher than
those of fumed silica alone. Consequently, good flow properties of LSP products were observed. On
the other hand, flowability, densities, and compactibility of directly compressible excipients (lactose,
dicalcium phosphate dihydrate, and microcrystalline cellulose) were not adversely affected when
mixed with LSPMelissa
officinalis L. (M.o.), Cardus marianus L. (C.m.), and Peumus boldus L. (P.b.) were used to load
silica support. The release of boldine from LSP (P.b.) reached 100% in HCl 0.1 N solution and only
approximately 70% in water. Some physicalmechanical properties of LSP (M.o. and C.m.) alone
and LSPexcipient mixtures were determined. The densities (bulk and tap) of LSP were higher than
those of fumed silica alone. Consequently, good flow properties of LSP products were observed. On
the other hand, flowability, densities, and compactibility of directly compressible excipients (lactose,
dicalcium phosphate dihydrate, and microcrystalline cellulose) were not adversely affected when
mixed with LSP(M.o.), Cardus marianus L. (C.m.), and Peumus boldus L. (P.b.) were used to load
silica support. The release of boldine from LSP (P.b.) reached 100% in HCl 0.1 N solution and only
approximately 70% in water. Some physicalmechanical properties of LSP (M.o. and C.m.) alone
and LSPexcipient mixtures were determined. The densities (bulk and tap) of LSP were higher than
those of fumed silica alone. Consequently, good flow properties of LSP products were observed. On
the other hand, flowability, densities, and compactibility of directly compressible excipients (lactose,
dicalcium phosphate dihydrate, and microcrystalline cellulose) were not adversely affected when
mixed with LSP