Optimisation of biopharmaceutical performance and antifungal efficacy of mucoadhesive films with nystatin

LLABOT JM; SANCHEZ, NATALIA; PALMA S; MANZO, R; ALLEMANDI D; ALOVERO, F

Pharma Research Journal

Sudarshan Publication

Año: 2011 vol. 5 p. 193 - 205

0975-8216

The aim of this study was to improve the biopharmaceutical performance bioadhesive films containing nystatin in terms of swelling ratio, disintegration rate, drug release, adhesion and to evaluate the influence of the excipients on antifungal action. The composition of the films was modified by incorporating Poloxamer 407 (POL407), polymer selected by its known surfactant properties and the ability to limit the swelling exhibited by carbomer. Mixing time and proportion of POL407 were critical parameters affecting the swelling and disintegration of the films. The most satisfactory formulation was film A3 containing carbomer 974P (CB974P), sodium carboxymethylcellulose (NaCMC), POL407 and nystatin (Nys), in the respective proportions (0.25:0.25:0.3:0.2). This film exhibited appropriate swelling ratio and muchoadhesive properties, rapid drug release extended over time and improved antifungal activity as compared with previously developed films.