Transdermal Delivery of Probenecid: the Effects of Vehicles

LUCÍA LHEZ; DANIEL A. ALLEMANDI; SANTIAGO D. PALMA; NORA B. PAPPANO; NORA B.DEBATTISTA

ACTA FARM. BONAERENSE

COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES

Año: 2010 vol. 29 p. 602 - 606

0326-2383

Vehicles and enhancers effect on in vitro probenecid permeation through dermatomed abdominal pig skin was investigated. The permeability of different probenecid percentages dispersed in vehicles as vaseline, carbopol/ethanol/water and carbopol/propylene glycol was tested. The 1.3% L-menthol addition, as permeation enhancer, over probenecid/vaseline formulations showed the highest values for both, flux and permeation coefficient. Permeation experiments of the probenecid formulations in carbopol/ propylene glycol showed that the carbopol/probenecid concentration relation is the most important issue to be considered. Comparatively to lipophilic vehicle (vaseline), carbopol dispersions seen to be more convenient as vehicle for topical administration of probenecid. The results obtained from this study may be helpful in the development of a probenecid transdermal drug delivery system.in vitro probenecid permeation through dermatomed abdominal pig skin was investigated. The permeability of different probenecid percentages dispersed in vehicles as vaseline, carbopol/ethanol/water and carbopol/propylene glycol was tested. The 1.3% L-menthol addition, as permeation enhancer, over probenecid/vaseline formulations showed the highest values for both, flux and permeation coefficient. Permeation experiments of the probenecid formulations in carbopol/ propylene glycol showed that the carbopol/probenecid concentration relation is the most important issue to be considered. Comparatively to lipophilic vehicle (vaseline), carbopol dispersions seen to be more convenient as vehicle for topical administration of probenecid. The results obtained from this study may be helpful in the development of a probenecid transdermal drug delivery system.