Improved albendazole dissolution rate in pluronic 188 solid dispersions

CASTRO, SILVINA; SANCHEZ - BRUNI S F; LANUSSE CARLOS; ALLEMANDI DANIEL; PALMA SANTIAGO

AAPS PHARMSCI

AAPS

Lugar: New York; Año: 2010 vol. 11 p. 1518 - 1525

1522-1059

Solids dispersions (SDs) have been proposed as an alternative to improve the dissolution rateof low solubility drugs. SDs containing albendazole (ABZ) (5, 10, 25, and 50 % w/w) and poloxamer 188 (P188) as hydrophilic carrier were formulated. The obtained SDs were assessed in comparison to physical mixtures (PMs).Drug-polymer interactions in solid state were investigated using Fourier-transform infraredspectroscopy, scanning electron microscopy and x-ray diffraction analysis. No chemical interaction was found between ABZ and poloxamer. The dissolution profiles indicated that ABZ incorporated in SDs and PMs was rapidly released, reaching rapidly the steady state.Increased dissolution rates are usually observed at the highest polymer proportions. However, anopposite effect for SDs as well as for PMs was observed in the assays described here. The systems with the lowest P188 percentages (SD4, SD3; PM4, PM3) seemed to be more effective in increasing the ABZ dissolution rate. Such a result can be attributed to the fact that concentrated aqueous solutions ofPoloxamer may form thermo-reversible gels. The physical-mechanical properties indicated that SDs possess improved flow and compacting properties compared to PMs. Thus, ABZ SDs would be more convenient for solid dosage form design and manufacture.