"Experimental Argentine hemorrhagic Fever: myocardial involvement in the Cebus monkey".

OUBIÑA JR,CARBALLAL G.; MILEI J, BOLOMO J, MOLINOLO A,

JOURNAL OF MEDICAL PRIMATOLOGY

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 1986 vol. 14 p. 391 - 397

0047-2565

Four Cebus apella monkeys, to test a recently proposed model for testing neurovirulence of Junín virus (JV) strains, were intracerebrally infected with 10(5) LD50 of the XJ clone 3 strain of JV. There were no significant electrocardiographic abnormalities or gross lesions, but all infected monkeys exhibited a varying degree of histologic myocardial lesions including focal lymphoblastic infiltrates, vascular ruptures, and mild interstitial reactive change. One Cebus showed lymphocytic infiltrates in the caudal portion of the A-V node without specific cell involvement. These preliminary results demonstrate cardiac involvement in experimental infection of the Cebus monkey with Junín virus.