INVESTIGADORES
OUBIÑA Jose Raul
artículos
Título:
"Circulating interferon in the guinea pig infected with the XJ prototype Junin virus strain".
Autor/es:
DEJEAN CB, TEYSSIÉ AR.; OUBIÑA JR, CARBALLAL G,
Revista:
JOURNAL OF MEDICAL VIROLOGY
Editorial:
WILEY-LISS, DIV JOHN WILEY & SONS INC
Referencias:
Lugar: New York; Año: 1988 vol. 24 p. 97 - 99
ISSN:
0146-6615
Resumen:
The interferon (IFN) induction capacity of the XJ prototype strain of Junín virus (JV) was investigated in the guinea pig model. Circulating alpha IFN was detected in 50% of the animals from days 2 to 9 postinfection (pi) and in 100% at day 11 pi, when all animals were in the premortem stage. Individual levels ranged from 20 to 1,280 guinea pig IFN units (GPIFNU)/ml. A correlation between XJ strain virulence and IFN titers was recorded. A possible role of IFN as a pathogenic factor in the outcome of the disease is discussed.
