INVESTIGADORES
MAYORGA Luis Segundo
congresos y reuniones científicas
Título:
Regulation of dendritic cells intracellular trafficking by SNX17 during antigen cross-presentation
Autor/es:
DINAMARCA, S; ZALAZAR, A; CROCE, C; MAYORGA, LS; CEBRIAN, I
Lugar:
Buenos Aires
Reunión:
Congreso; ReuniĆ³n Conjunta Sociedades Biociencias; 2017
Institución organizadora:
SAIB
Resumen:
Cross-presentation by MHC class I molecules allows the detectionof exogenous antigens by CD8+ T lymphocytes. This process is crucialto initiate cytotoxic immune responses against many pathogens(i.e. Toxoplasma gondii) and tumors. To achieve efficient cross-presentation,dendritic cells (DCs) have developed highly specializedadaptations of their endocytic network. Consequently, DCs are themost potent antigen presenting cell type to accomplish this immunologicalprocess. However, a complete view of the many moleculareffectors involved in antigen cross-presentation is still missing.Sorting nexin (SNX) proteins are characterized by the presence ofa phox-homology (PX) domain that interacts with elements of theendocytic pathway enriched with phosphatidylinositol-3-monophosphate.In this way, SNXs control key features of endocytosis, as wellas endosomal signaling, sorting and tubulation. In this study, we fo
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