ISLA Maria Ines
congresos y reuniones científicas
Evaluation of Candida sensibility against leaves fluid extracts of Sechium edule (Jacq) Swartz.
ORDOÑEZ A., VATTUONE M., ISLA M.I.
Congreso; XXI Jornadas de la Asociación de Biología de Tucumán; 2005
Asociación de Biología de Tucumán
Previous reports have showed the increase of infection by Candida parasilopsis, C. krusei, C. tropicalis and C. glabrata in hospitalary pediatric patients. These infections are difficult to control because the isolated species show different resistance according to the country, institution or patient. In a previous work we reported the antibacterial and antifungal activity of S. edule ethanolic extracts. The purpose of this work was to evaluate the activity of these extracts against Candida strains isolated from patients of Hospital de Niños, Tucumán. The minimal fungal concentration (MFC) was determined using the serial agar macrodilution and broth microdilution methods. Then, the results were compared with the synthetic antifungal drug, clotrimazole. The MFC values obtained were 80 µg/ml for C. parasilopsis and C. krusei and 160 µg/ml for C. glabrata. However, the most resistant strain was C. tropicalis with MFC values of 880µg/ml. Our results make S. edule ethanolic extracts, an ideal candidate for microbial control of Candida in the hospitalary sanitation.