INVESTIGADORES
ISLA Maria Ines
artículos
Título:
Zuccagnia ‐type Propolis from Argentina: A potential functional ingredient in food to pathologies associated to metabolic syndrome and oxidative stress
Autor/es:
SALAS, ANA L.; MERCADO, MARÍA INÉS; EUGENIA ORQUEDA, MARIA; CORREA URIBURU, FLORENCIA M.; GARCÍA, MARIA ELENA; PÉREZ, MARÍA JORGELINA; ALVAREZ, MARÍA DE LOS ANGELES; PONESSA, GRACIELA I.; MALDONADO, LUIS MALDONADO; ZAMPINI, IRIS CATIANA; ISLA, MARÍA INÉS
Revista:
JOURNAL OF FOOD SCIENCE
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2020
ISSN:
0022-1147
Resumen:
The effect of Argentine propolis extracts against enzymes related to metabolic syndrome and oxidative stress,as well as the botanical origin of raw propolis, were studied. Histological and chemical analyses of propolis samplesrevealed that the botanical origin is Zuccagnia punctata, an Argentine medicinal plant. The melissopalynological analysisshowed both pollen grains of Z. punctata and the other plant species. This result indicates that the differences found inthe botanical remains compared to the palynological studies may have been caused by the bees selecting resinous shrubsmainly of Z. punctata for the production of propolis and other plants with flowers for the production of honey.The richness of propolis was remarkable in two flavonoid precursors (2´,4´-dihydroxy-3´-methoxychalcone, 2´,4´-dihydroxychalcone), the major chemical components of Z. punctata. The hydroalcoholic extracts of Argentine propolisand Z. punctata were able to inhibit enzymes associated with the metabolic syndrome, including α-glucosidase, α-amylaseand lipase, with IC50 values between 7 to 14, 37 to 48, and 13 to 28 μg/mL, respectively. Biological activity wasmainly attributed to chalcones. Oxygen and nitrogen reactive species scavenging activity was determined by the assaysof superoxide radical (O2?−), hydroxyl radical (HO?), hydrogen peroxide (H2O2), nitric oxide (NO?), and cation radical(ABTS?+). Results showed SC50 values between 115 to 278, 12.50 to 46; 39 to 92; 50 to 104.50 and 23 to 33.75 μg/mL,respectively. This study suggests for the first time that propolis from Argentina is highly effective in inhibiting enzymesrelated to the metabolic syndrome and in free-radical scavenging that would justify its use as a dietary supplement or as afunctional ingredient in special food.