Alteraciones citogenéticas en caninos de razas puras con criptorquidismo

SALDEÑA E; HYNES V ; FERRÉ D M; N GORLA,

BUENOS AIRES

Congreso; Primer Congreso de la Sociedad Latinoamericana de Reproducción Animal; 2015

SOCIEDAD LATINOAMERICANA DE REPRODUCCION ANIMAL

Citogenetic alterations in purebred dogs with criptorchidismDuring canine domestication, conformational or behavioral characteristics were selected, causing an increase in closed crosses and inbreeding with the consequent reduction of the gene flow. Cryptorchidism is the failure of the descent from the abdomen into the scrotum of one or both testicles, resulting more common in purebred dogs. The incidence in the canine population is 3.3 to 6.8%. Five purebred dogs with cryptorchidism were studied by clinical inspection, ultrasound, histopathology and cytogenetic analysis. Among the 5 animals studied, three had normal karyotype= 78, XY. A Cocker Spaniel with bilateral cryptorchidism had 40% of metaphases with chromosome 1q+. A Yorkshire Terrier with bilateral cryptorchidism, presented testicular atrophy in the histopathological study, and mosaicism or chimera with karyotype= 78, XY / 78, XX (80%/ 20%). Finally, a Miniature Poodle with unilateral cryptorchidism retained testis showed Sertoli cell tumor histopathology, and cytogenetic alterations were not detected. The1q + rearrangement found in cocker spaniel with bilateral cryptorchidism can be related to the chromosomal location of one of the candidate genes in dogs , the ESR1 gene for estrogen receptor located on the q arm of chromosome 1. The mosaics / chromosomal chimeras have been reported in connection with the canine cryptorchidism.