INTRAVENOUS PHARMACOKINETICS OF CIPROFLOXACIN IN GOATS

H. GARCÍA VANDO; N. GORLA; G. POLONI; N. TROTTI; G. PRIETO; C. ERRECALDE

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

ELSEVIER SCIENCE BV

Año: 2000 p. 77 - 79

0924-8579

The pharmacokinetics of ciprofloxacin in goats was studied following intravenous administration. A single dose of 10 mg/ kg was administered as an intravenous bolus, and serum samples were collected at predetermined intervals over a 24 hours period. Ciprofloxacin levels were measured using high pressure liquid chromatography, and the resulting concentration versus time curve was analyzed using a non linear regression analysis. The data were best represented by a two compartment pharmacokinetic model with a mean elimination half- life of 2.72 + 1.04 h. Mean robust pharmacokinetic parameters obtained were area under the curve (AUC: 10.320 + 5.137 ug/ ml.h ), mean residence time (MRT: 3.334 + 1.428 h), apparent volume of distribution (Vdss: 3.373 + 0.893 l/kg) and total body drug clearance (tCl 19.596 + 9.059 ml/ min/ Kg ). CFX in goats shows the general pharmacokinetic characteristics of a typical fluoroquinolone antibacterial agent. It is expected ciprofloxacin to reach mean serum concentrations against susceptible organisms while 10 mg/ kg of the antimicrobial is administered intravenous each 12 hours intervals to goats.