INVESTIGADORES
GORLA Nora Bibiana Maria
artículos
Título:
INTERACTION OF BENZNIDAZOLE REACTIVE METABOLITES WITH RAT LIVER DNA AND NUCLEAR PROTEINS
Autor/es:
GORLA N B, DÍAZ GÓMEZ M I, CASTRO J A
Revista:
ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE
Editorial:
ARCH INT PHARMACODYNAMIE
Referencias:
Año: 1986 p. 22 - 31
ISSN:
0003-9780
Resumen:
Benznidazole BZ is one of the drugs used in the chemotherapy of Chagas disease.Microsomal suspensions anaerobically activated BZ in the presence of NADPH to metabolites that covalently bind to proteins or to DNA incorporated into de incubation mixture. Nuclear preparations were also able to anaerobically activate BZ to reactive metabolites that bind covalently their DNA and Proteins. The process was enzymatic and required NADPH.
