INVESTIGADORES
GONZALEZ-JOSE Rolando
congresos y reuniones científicas
Título:
Ancestry Perception Bias in Latin American Admixed Populations
Autor/es:
ADHIKARI, K; RUIZ-LINARES, A; BEDOYA, G; BORTOLINI, MARIA CATIRA; CANIZALES-QUINTEROS, S; GALLO, C; GIBBON, S; GONZÁLEZ JOSÉ, ROLANDO; ROTHHAMMER, F; THE CANDELA CONSORTIUM
Reunión:
Congreso; Annual Meeting of the American Society of Human Genetics. San Francisco, CA, USA.; 2012
Resumen:
CANDELA (Consortium for the Analysis of the
Diversity and Evolution of Latin America) is an international collaboration
involving researchers from the UK
and several Latin American countries (Argentina,
Brazil, Chile, Colombia,
Mexico and Peru). With its
history of extensive population mixture, Latin America
in many ways represents a form of natural experiment providing an advantageous
opportunity to explore genetic and social aspects related to human biological
diversity. CANDELA aims to perform a multidisciplinary study of a wide range of
phenotypic, social and genetic data for about 8,000 Latin American individuals.
An initial analysis including 40 Ancestry Informative Markers enabled
estimation of individual Amerindian, European and African ancestry proportions
(using STRUCTURE software) and their contrast with self-reported ancestry as
well as with a range of phenotypic and social variables. As expected, we find a
significant positive correlation of the genetic and self-perceived ancestries.
However, across the region, we observe strong biases in self-perceived relative
to genetic ancestry. For example, individuals with low to moderate (0-40%)
European genetic ancestry tend to self-perceive their European ancestry as even
lower; while individuals with high (>60%) African or Native American genetic
ancestries tend to estimate these ancestries as even higher. There is also
significant variation across countries in these biases, as much as 20-30%
difference in the genetic v. self-perceived ancestries - in the Mexican or
Chilean samples, individuals underestimate their Native American ancestry by
about 20%, while in the Brazilian or Colombian samples individuals overestimate
their Native American ancestry by a similar amount. Several factors could
underlie these biases in self-perception of ancestry. For instance, we find
that individuals with darker skin color significantly overestimate their
African ancestry. We also find a strong effect of gender - relative to men,
women underestimating their European ancestry and overestimating their African
ancestry. Overall, we find evidence of a complex interplay of social and
phenotypic factors in self-perception of ancestry: while visible traits such as
skin color have an important impact, perception of ancestry is also intricately
linked with social factors, as evidenced by variation across the countries
examined.