Synthesis of Tetrasubtituted Tetrahydropyrans by a Tandem SN2´-Prins Cyclization

MARTÍN, VÍCTOR S.; SCOCCIA JIMENA; SIXTO JOSÉ PÉREZ MORENO; JUAN I. PADRÓN

Huelva

Congreso; XXVI Reunión Bienal de Química Orgánica; 2016

Real Sociedad Española de Química

The tetrahydropyran are common structural units present and widespread in the natural products. This products has powerful bioactivity against many disease [1]. Therefore, the development of new and sustainable methodologies allowing the efficient access to these oxygen heterocycles represents a target as well as a challenge for synthetic organic chemists. In this work, we shall show the cyclization tandem of chlorovinyl alcohols to obtain the tetrasubstituted tetrahydropyran through iron (III) salts catalysis with diastereoselectivity and capacity of derivatization