MAGNETIC NANOPARTICLES STABILIZED WITH ORGANIC ACIDS AS SPECIFIC CONTRAST AGENTS FOR ATHEROSCLEROSIS DIAGNOSIS

GABRIELA MONTIEL SCHNEIDER; MARIELA AGOTEGARAY; VERÓNICA LASSALLE

Encuentro; VII REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE NANOMEDICINA (NANOMEDAR); 2016

IntroductionAtherosclerosis and its vascular complications, are the main cause of death in the western world. Identification of vulnerable plaques which are prone to rupture, releasing thrombus into circulation is essential for a better care of patients presenting this pathology. Magnetic nanoparticles are being employed as efficient tools to the earlier and selective detection of unstable plaques by Magnetic Resonance Imaging along the last years. ObjetiveDesign and characterize water dispersible iron oxide magnetic nanoparticles with suitable coatings in order to be efficiently employed in the detection of atherosclerotic plaques by MRI. The goal is to induce the accumulation of nanoparticles in macrophages, calcifying microvesicles presents in atherosclerotic plaques, according to previous reports.