INQUISUR 21779
INSTITUTO DE QUIMICA DEL SUR
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Multicomponent Synthesis of Heterocycles Catalysed by Copper Nanoparticles
Autor/es:
MARÍA JOSE ALBALADEJO; FRANCISCO ALONSO; YANINA MOGLIE
Lugar:
Budapest
Reunión:
Conferencia; 20th International Conference on Organic Synthesis; 2014
Institución organizadora:
Universidad de Budapest
Resumen:
In the last few years, we have been interested in the application of supported copper nanoparticles to multicomponent reactions, such as the A3 coupling or the click synthesis of 1,2,3-triazoles from different azido precursors in water. More recently, a one-pot protocol for the synthesis of 1,2,3-triazoles has been developed starting from inactivated alkenes and based on two click reactions: the azidosulfenylation of the carbon-carbon double bond and the copper-catalysed azide-alkyne cycloaddition (Scheme 1).High yields of the β-methylsulfanyl triazoles have been attained using CuNPs/C as catalyst, with other
commercial copper catalysts being completely inactive.
The versatility of the CuNPs/C catalyst allowed the multicomponent synthesis of indolizines(from pyridine-2-carbaldehyde derivatives, secondary amines, and terminal alkynes) in dichloromethane and the synthesis of heterocyclic chalcones under solvent-free conditions(Scheme 2. The reactivity of the aforementioned indolizines has also been studied.
