INQUISUR   21779
INSTITUTO DE QUIMICA DEL SUR
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Synthesis and Antimicrobial Activities of Gold(I) N-heterocyclic Carbene Complexes
Autor/es:
G.A. FERNÁNDEZ; M.S. VELA GUROVIC; N.L. OLIVERA; A.B. CHOPA; G.F. SILBESTRI
Lugar:
internet
Reunión:
Congreso; 16th International Electronic Conference in Synthetic Organic Chemistry (16 ECSOC),; 2012
Resumen:
Water-soluble gold(I) complexes [1-mesityl-3-(3-sodiumsulfonatopropyl)imidazol-2-ylidene] gold(I) Chloro (3) and [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl)imidazol-2-ylidene] gold(I) Chloro (4) were prepared, in high yield, by carbene transmetallation from the appropriate NHC silver complex with chloro tetrahydrothiophene gold ([AuCl(tht)]). The antimicrobial properties of both gold(I) compounds and the respective ligands were assessed by agar diffusion assay and the broth macrodilution method against both Gram-positive and negative bacteria. MICs values (> 128 ug/ml) were superior to those displayed by the reference antibiotics penicillin G and streptomycin.