Design and Synthesis of New SERMs Based on Flavonoids Scaffolds

ANA ESTÉVEZ BRAUN; ANGEL G. RAVELO; MARÍA JULIA CASTRO; ANGEL AMESTY

Tenerife

Simposio; 9th Spanish-Italian Symposium on Organic Chemistry, SISOC-IX; 2012

sERMs (selective Estrogen ReceptorsJ{odulatot)-gq chemical entities of low molecular weight that interacwt ith estr.og-¿e"np *´,:^^q.^tq;il^´eilpj,-iñü;ü;ü sdmulate estrogenr eceptorso f different target tlssues.^,. or inhibitt he rney nave great p-h1¡llcological Pitential as they are prescribed in estrogen dependentb reast cancer as well as in the treatmento ? menopauses ymtomi and in the iiüment of osteosporosis women´ - sERMs are also important from^ttrep óíni in diseases.´ óf "i.* "Frh;;;;r"tion of cardiovascular POSTERS Acknowledgements: C02-01) for financial doctoral fellowship. References: I Diaz-chico´ B´N´, Diaz-chico, J´c´,.Escric, E, Moduladores selecttvos de los receptores de estrogenos (sERMs). , fnectos !fuy?t y clínicos.e d.SCM. anagemen2t.0 0J. l *;tr, 3 #T:p.; : l ;;, í;;ü;;;;"do cr in oto síab á sic a .edE. A.t .A s . 20006s, - s2 aiRD o:nt:gxl,ti al,otwou,r.T;i, ,q"r u´*o;.;."wiu,",..i_l ;oifdl ;; ;;;:*""-Lí;E;:,´;´";;.:;´|"íí;i;;i:iJ;:,";í;iÍ;;;n"";*ü í?;it;i: 716-72(6´., , BioorgM. edc. hem.2001e7, : @ t39 In this communicatio.nw e. will report the desipn and synthesis of new chemical entities basedo ´ flavonoid core through a biomimetic approach.{ we will also reoort its estro8enica ctiüty ag{ the key interactionso f representative the binding pociceto f estrogén, r".ptorrtTiis