INQUISUR   21779
INSTITUTO DE QUIMICA DEL SUR
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Synthesis and characterization of hydroxyapatite "nanorods" with potential biomedical application
Autor/es:
D' ELÍA NOELIA LAURA; GRAVINA ANABELA NOEL; MESSINA PAULA VERÓNICA
Lugar:
Bahía Blanca
Reunión:
Congreso; IV Congreso Argentino de Material Blanda; 2012
Institución organizadora:
Ifisur
Resumen:
Bone can be considered as a biological hybrid material composed of an organic component, collagen, and an inorganic one, nanocrystalline Carbonate hydroxyapatite (HAP), with lengths between 20 - 50 nm and shaped of rods (Poinem et al., 2009). The synthetic hydroxyapatite (Ca10(PO4)6(OH)2) has been extensively used as a bone substitute material due to its chemical and structural similarity with natural bone mineral besides to its good biocompatibility and osteointegration. Recently it has been used as drug delivery vehicle due to its high binding affinity with a variety of molecules (Qingguo et al., 2007). In addition, few researches have been reported of HAP nanoparticles as a gene vector because of its high DNA binding capacity and good transfection efficiency (Wu et al., 2010). The control of its shape and morphology for increase the ratio surface area - volume is important due to HAP nanoparticles are efficient to improve the contact and stability at the artificial/natural bone interface (Li and de Groot, 1994). It is becoming important to develop nanoparticles of HAP with precise control of size, morphology, degree of crystallinity and chemical composition. One way to obtain such HAP nanoparticles are synthetic systems using self-assembled amphiphilic molecules as structures directors. In particular, the controlled synthesis of inorganic micro and nanostructures with microemulsions has attracted intensive interest because of the possibility of assembly and integration of nanoscale building blocks into ordered superstructures or complex functional architectures (Qi, 2010) like complex structure of bone. The aim of this work is to obtain HAP nanocrystals using a biomimetic synthesis with micelles as structure directing agents.