INTERACTION BETWEEN ASCORBYL PALMITATE AND WATER

ERICA P. SCHULZ, LUCIANO BENEDINI, PAULA V. MESSINA, PABLO C. SCHULZ, SANTIAGO D. PALMA, DANIEL A. ALLEMANDI.

Congreso; 1º Reunión Internacional de Ciencias Farmaceuticas (RICiFA; 2010

The knowledge of the interaction between water and drugs having pharmaceutical applications is of fundamental importance for the design of applications. The interplay of experimental, structural and molecular dynamics simulation gives a complete picture of this interaction. We have performed differential scanning calorimetry (DSC) experiments and have interpreted the results on the basis of a geometric model of hydrated crystals and lamellar liquid crystals of ascorbyl palmitate (Asc16) and molecular dynamics simulation (MDS).