INQUISUR   21779
INSTITUTO DE QUIMICA DEL SUR
Unidad Ejecutora - UE
artículos
Título:
Antimicrobial properties of tetracycline and minocycline- montmorillonites
Autor/es:
PAROLO, M.E.; AVENA, M.; PETTINARI, G.R.; ZAJONKOVSKY, I.; VALLES, J.M.; BASCHINI, M.T.
Revista:
APPLIED CLAY SCIENCE
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2010 vol. 49 p. 194 - 199
ISSN:
0169-1317
Resumen:
The antimicrobial activity of adsorption complexes of antibiotics from the tetracycline family on sodium and
calcium montmorillonite was evaluated for their use in human and veterinary medicine. Tetracycline (TC)
and minocycline (MC) adsorption on Patagonian montmorillonite was studied as a function of pH using
batch experiments, X-ray diffraction (XRD) and IR spectroscopy. The adsorption was high at low pH and
decreased continuously as pH increased. Adsorption of MC was higher than adsorption of TC. TC and MC
were intercalated into the interlayer space of montmorillonite as deduced from the increase of the basal
spacing. IR spectroscopy suggested that NHR3
+ and other polar groups were directly involved in the
interaction with montmorillonite. The antimicrobial activity, measured by inhibition tests, was maintained
by the antibiotics after adsorption on montmorillonite, whereas unreacted montmorillonite did not show
any antibacterial activity. The excellent activity shown by the TC and MC complexes provides a promising
interaction with montmorillonite. The antimicrobial activity, measured by inhibition tests, was maintained
by the antibiotics after adsorption on montmorillonite, whereas unreacted montmorillonite did not show
any antibacterial activity. The excellent activity shown by the TC and MC complexes provides a promising
+ and other polar groups were directly involved in the
interaction with montmorillonite. The antimicrobial activity, measured by inhibition tests, was maintained
by the antibiotics after adsorption on montmorillonite, whereas unreacted montmorillonite did not show
any antibacterial activity. The excellent activity shown by the TC and MC complexes provides a promising
interaction with montmorillonite. The antimicrobial activity, measured by inhibition tests, was maintained
by the antibiotics after adsorption on montmorillonite, whereas unreacted montmorillonite did not show
any antibacterial activity. The excellent activity shown by the TC and MC complexes provides a promising
3
+ and other polar groups were directly involved in the
interaction with montmorillonite. The antimicrobial activity, measured by inhibition tests, was maintained
by the antibiotics after adsorption on montmorillonite, whereas unreacted montmorillonite did not show
any antibacterial activity. The excellent activity shown by the TC and MC complexes provides a promising
interaction with montmorillonite. The antimicrobial activity, measured by inhibition tests, was maintained
by the antibiotics after adsorption on montmorillonite, whereas unreacted montmorillonite did not show
any antibacterial activity. The excellent activity shown by the TC and MC complexes provides a promising
and other polar groups were directly involved in the
interaction with montmorillonite. The antimicrobial activity, measured by inhibition tests, was maintained
by the antibiotics after adsorption on montmorillonite, whereas unreacted montmorillonite did not show
any antibacterial activity. The excellent activity shown by the TC and MC complexes provides a promising
field of application, in particular for the formulation of topical products.eld of application, in particular for the formulation of topical products.