Synthesis and characterization of N-propyl-N-methylene phosphonic chitosan derivative

ADRIANA ZUÑIGA; ADRIANA DEBBAUDT; LILIANA ALBERTENGO; MARÍA SUSANA RODRÍGUEZ

CARBOHYDRATE POLYMERS

ELSEVIER SCI LTD

Año: 2009

0144-8617

A simple methodology for the preparation of a new chitosan derivative called N-propyl-N-methylene phosphonic chitosan (PNMPC) is proposed. Introduction of a propyl chain onto a modified chitosan (N-methylene phosphonic chitosan) offers the presence of hydrophobic and hydrophilic branches for controlling solubility properties of the new derivative. Its chemical identity was determined by FT-IR, 1H, 13C and 31P NMR spectroscopy. The degree of propyl substitution estimated by elemental analysis was 0.64. Furthermore derivative molecular weight is about 60 103, X-ray diffraction and SEM showed certain degree of crystallinity and homogeneous surface with a rather packed structure. This derivative opens new perspectives in food, pharmaceutical and cosmetic fields.N-propyl-N-methylene phosphonic chitosan (PNMPC) is proposed. Introduction of a propyl chain onto a modified chitosan (N-methylene phosphonic chitosan) offers the presence of hydrophobic and hydrophilic branches for controlling solubility properties of the new derivative. Its chemical identity was determined by FT-IR, 1H, 13C and 31P NMR spectroscopy. The degree of propyl substitution estimated by elemental analysis was 0.64. Furthermore derivative molecular weight is about 60 103, X-ray diffraction and SEM showed certain degree of crystallinity and homogeneous surface with a rather packed structure. This derivative opens new perspectives in food, pharmaceutical and cosmetic fields.N-methylene phosphonic chitosan) offers the presence of hydrophobic and hydrophilic branches for controlling solubility properties of the new derivative. Its chemical identity was determined by FT-IR, 1H, 13C and 31P NMR spectroscopy. The degree of propyl substitution estimated by elemental analysis was 0.64. Furthermore derivative molecular weight is about 60 103, X-ray diffraction and SEM showed certain degree of crystallinity and homogeneous surface with a rather packed structure. This derivative opens new perspectives in food, pharmaceutical and cosmetic fields.1H, 13C and 31P NMR spectroscopy. The degree of propyl substitution estimated by elemental analysis was 0.64. Furthermore derivative molecular weight is about 60 103, X-ray diffraction and SEM showed certain degree of crystallinity and homogeneous surface with a rather packed structure. This derivative opens new perspectives in food, pharmaceutical and cosmetic fields.31P NMR spectroscopy. The degree of propyl substitution estimated by elemental analysis was 0.64. Furthermore derivative molecular weight is about 60 103, X-ray diffraction and SEM showed certain degree of crystallinity and homogeneous surface with a rather packed structure. This derivative opens new perspectives in food, pharmaceutical and cosmetic fields.103, X-ray diffraction and SEM showed certain degree of crystallinity and homogeneous surface with a rather packed structure. This derivative opens new perspectives in food, pharmaceutical and cosmetic fields.