Simple and novel strategies to achieve shape and size control of magnetite nanoparticles intended for biomedical applications

PAMELA AZCONA; ROBERTO ZYSLER; VERÓNICA LASSALLE

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016 vol. 504 p. 320 - 330

0927-7757

Monodisperse magnetite nanoparticles (MNPs) with controlled sizes and shapes were prepared. Thesynthesis was carried out by traditional and inverted co-precipitation method with some modificationssuch as presence of visible light, room temperature and absence of inert atmosphere. Sodium dodecylsulphate (SDS) was employed as stabilizer. The mentioned experimental parameters were convenientlyadjusted to obtain suitable MNPs, to be efficiently employed in biomedical applications. In particular thesize, shape, surface charge and magnetic properties were evaluated. MNPs were thoroughly characterized.From characterization data, it emerged that the inverted co-precipitation in presence of visible lightrendered mainly nanorods. Modifying the SDS concentration the shape was tuned from nanorods tonanospheres and finally, at higher concentrations, nanocubes were obtained. All prepared formulationsresulted hydrophilic. This property was justified in terms of the stabilization mechanism of SDS.Stability of MNPs aqueous dispersions was evaluated regarding to the variation of hydrodynamicdiameter as a function of the time. In this regard, all the formulations resulted stable during, at least, 30days. The prepared nanosystems exhibited satisfactory magnetic properties with saturation magnetizationslightly lower than raw magnetite.The combination of size, shape, surface charge, hidrophilicity and magnetic behaviour make the magneticnanosystems here obtained highly suitable and promising to diagnostic and therapeutic applications.