Striped, bioactive Ce-TiO2 material with peroxynitrite-scavenging activity

GRAVINA ANABELA NOEL; RUSO JUAN MANUEL; LAIUPPA JUAN ANDRÉS; SANTILLÁN GRACIELA EDITH; MARCO-BROWN JOSÉ LUIS; D'ELÍA NOELIA LAURA; MESSINA PAULA VERÓNICA

Journal of Material Chemistry B

ROYAL SOC CHEMISTRY

Año: 2014 vol. 2 p. 834 - 845

2050-750X

Controlling aligned fiber micro-architectures to simulate extracellular matrix inducing important biological functions is a key challenge in regard to successful tissue regeneration. Here we present a bottom-up microemulsion mediated strategy to obtain highly bioactive and biocompatible, striped Ce-TiO2 nano-crystalline superstructures with ONOO- scavenging activity. The employment of a bulkier organic ceria precursor on the material synthesis has several concurrently effects: (I) influencing the interfacial microemulsion droplet elasticity to create an aligned distribution of prismatic anatase nano-particles causing the final lined morphology; (II) stabilizing the anatase active phase in a fine dispersed state and improving it resistance to the thermal anatase-rutile conversion; (III) indirectly favoring the rapid formation on the material surface of a hydroxyapatite layer composed of spherical-like globules with 3-5 μm in diameter essential for bone-bonding; and finally (IV) accelerating the ONOO- degradation to a less harmful species NO2- and O2.