Antibacterial Properties of Water-Soluble Gold(I) N-heterocyclic Carbene Complexes

G.A. FERNANDÉZ; M.S. VELA GUROVIC; N.L. OLIVERA; A.B. CHOPA; G.F. SILBESTRI

JOURNAL OF INORGANIC BIOCHEMISTRY

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 2014 vol. 135 p. 54 - 57

0162-0134

The antibacterial properties of water-soluble gold(I) complexes [1-methyl-3-(3-sulfonatopropyl)imidazol-2- ylidene]gold(I) chloride (C1), [1-mesityl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C2), [1-(2,6- diisopropylphenyl)-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C3) and [1,3-bis(2,6-diisopropyl- 4-sodiumsulfonatophenyl)imidazol-2-ylidene]gold(I) chloride (C4) and the respective ligands were assessed by agar diffusion and broth macrodilutionmethods against Gram-positives Staphylococcus aureus, Enterococcus faecalis and Micrococcus luteus and the Gram-negative bacteria Yersinia ruckeri, Pseudomonas aeruginosa and Escherichia coli. Viability after treatmentswas determined by direct plate count. The bactericidal activity displayed by C1 and C3 was comparable to that of AgNO3.