INQUISUR 21779
INSTITUTO DE QUIMICA DEL SUR
Unidad Ejecutora - UE
artículos
Título:
Ultrasound-assisted synthesis of benzophenones by Stille cross-coupling reactions. Optimization via experimental design
Autor/es:
M. LUONG; C.E.DOMINI; SILBESTRI, G.F.; ALICIA B. CHOPA
Revista:
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Editorial:
ELSEVIER SCIENCE SA
Referencias:
Lugar: Amsterdam; Año: 2013 vol. 723 p. 43 - 48
ISSN:
0022-328X
Resumen:
A series of diaryl ketones have been synthesized in good to excellent yields through the selective cross-coupling reaction of benzoyl chlorides with arylstannanes using a sonochemical variation of the Stille coupling. Ultrasound significantly enhances this useful organometallic transformation affording the desired products in higher yields and shorter reaction times than conventional reactions. The scope of the protocol has been explored with a selection of arylstannanes and different acyl chlorides as reaction partners. Remarkably, no by-products resulting from homo-coupling could be detected. The ultrasound-promoted cross-coupling reaction was optimized through experimental design.
