INQUISUR   21779
INSTITUTO DE QUIMICA DEL SUR
Unidad Ejecutora - UE
artículos
Título:
Therapeutic properties, SOD and catecholase mimetic activities of novel ternary copper(II) complexes of the anti-inflammatory drug Fenoprofen with imidazole and caffeine
Autor/es:
MARIELA A. AGOTEGARAY; MARIANA DENNEHY; MÓNICA A. BOERIS; MARÍA A. GRELA; ROBERT BURROW; OSCAR V. QUINZANI
Revista:
POLYHEDRON
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2012 vol. 34 p. 74 - 83
ISSN:
0277-5387
Resumen:
The copper(II) ternary complexes of the non-steroidal anti-inflammatory drug Fenoprofen (Hfen) and the
biologically relevant molecules imidazole (im) and caffeine (caf) as auxiliary ligands were investigated as
novel anti-inflammatory agents. The new copper(II) complexes with formula [Cu(fen)2(im)2] (1) and
Cu2(fen)4(caf)2 (2) were synthesized from the dinuclear complex [Cu2(fen)4(dmf)2] and characterized
by IR, UV?Vis, EPR spectral and elemental analysis. The molecular structure of complex 1 was determined
by X-ray crystallography. Both complexes 1 and 2 present enhanced and prolongued anti-inflammatory
properties against the parent drug calcium Fenoprofenate, Ca(fen)2_2H2O, with a better performance for
complex 1. Ternary complexes are potential models for several mono and poly-nuclear metal enzymes.
The measured superoxide dismutase (SOD) mimetic activities of the complexes indicated a higher SOD
mimic activity for complex 2 (IC50 of 0.24 lM) than complex 1 (IC50 of 0.70 lM), and also than the native
enzyme evaluated by the same method (IC50 of 0.480 lM). The catecholase activity of the complexes
toward the aerobic oxidation of 3,5-di-tert-butylcatechol (dtbc) onto 3,5-di-tert-butylquinone (dtbq)
showed that both complexes have moderate catalytic oxidase activity.