Ultrasound promoted Barbier reactions and Csp3 - Csp2 Stille coupling for the synthesis of diarylmethanes and substituted benzophenones

R.A. OCAMPO; L. C. KOLL; S. D. MANDOLESI

ULTRASONICS SONOCHEMISTRY.

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2012 vol. 20 p. 40 - 46

1350-4177

Here we present the preparation of a variety of diarylmethanes obtained via ultrasound Stille couplingunder palladium catalysis between some substituted aryl compounds and benzyltributyltin compoundsgenerated through sonicated Barbier reaction in a very short time reaction and excellent yield. The studyreported below compares different methods to optimize the synthesis of usually unstable benzyltinderivatives and is another contribution to the investigation of Csp3?Csp2 coupling process involving benzyl?aryl reagents. Substituted carboxylated benzophenones were easily prepared in a very good yield byoxidation of some diarylmethanes