1. Therapeutic properties, SOD and catecholase mimetic activities of novel ternary copper(II) complexes of the anti-inflammatory drug phenoprophen with imidazole and caffeine.

AGOTEGARAY MARIELA A.; BOERIS MÓNICA A. ; GRELA MARÍA A. ; ROBERT ALAN BURROW; OSCAR VALENTÍN QUINZANI; DENNEHY MARIANA

POLYHEDRON

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2012 vol. 34 p. 74 - 83

0277-5387

The copper(II) ternary complexes of the non-steroidal anti-inflammatory drug Fenoprofen (Hfen) and thebiologically relevant molecules imidazole (im) and caffeine (caf) as auxiliary ligands were investigated asnovel anti-inflammatory agents. The new copper(II) complexes with formula [Cu(fen)2(im)2] (1) andCu2(fen)4(caf)2 (2) were synthesized from the dinuclear complex [Cu2(fen)4(dmf)2] and characterizedby IR, UV–Vis, EPR spectral and elemental analysis. The molecular structure of complex 1 was determinedby X-ray crystallography. Both complexes 1 and 2 present enhanced and prolongued anti-inflammatoryproperties against the parent drug calcium Fenoprofenate, Ca(fen)22H2O, with a better performance forcomplex 1. Ternary complexes are potential models for several mono and poly-nuclear metal enzymes.The measured superoxide dismutase (SOD) mimetic activities of the complexes indicated a higher SODmimic activity for complex 2 (IC50 of 0.24 lM) than complex 1 (IC50 of 0.70 lM), and also than the nativeenzyme evaluated by the same method (IC50 of 0.480 lM). The catecholase activity of the complexestoward the aerobic oxidation of 3,5-di-tert-butylcatechol (dtbc) onto 3,5-di-tert-butylquinone (dtbq)showed that both complexes have moderate catalytic oxidase activity.