INQUISUR   21779
INSTITUTO DE QUIMICA DEL SUR
Unidad Ejecutora - UE
artículos
Título:
Selective Synthesis of Mono- and Distannylpyridines from Chloropyridinols via an SRN1 Mechanism
Autor/es:
GUSTAVO F. SILBESTRI; MARCOS J. LO FIEGO; MARÍA T. LOCKHART; ALICIA B. CHOPA
Revista:
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Editorial:
ELSEVIER SCIENCE SA
Referencias:
Lugar: Amsterdam; Año: 2010 vol. 695 p. 2578 - 2585
ISSN:
0022-328X
Resumen:
A selective two-step synthesis of either mono- or distannylated pyridines from commercially available pyridinols, involving its conversion to the corresponding diethyl pyridyl phosphates (pyDEP) followed by the reaction with Me3SnNa in liquid ammonia, is described. The results obtained clearly indicate that the reactions proceed through a unimolecular radical nucleophilic substitution mechanism (SRN1) with intermediacy of a monosubstitution product.