Anticancer effects of two complexes derived from naringin and oxidovanadium(IV) cation

RESTREPO-GUERRERO, GONZALO; GOITÍA, H.; FERRER E.G; WILLIAMS P.A.M.

Montevideo

Encuentro; VII Latin American Meeting on Biological Inorganic Chemistry; 2021

Universidad de la República, Uruguay

Two different solid complexes with the glycosilated flavonoid naringin (naringenin (7-O-neohesperidoside)) and the oxidovanadium(IV) cation were prepared and characterized. Complex (1), [VO(Nar)2].8H2O (VONar), was prepared as previously reported [1] using a different synthetic method. The solid obtained at pH 9 coordinates through the flavonoid moiety (C=O and O- groups of rings A and C, respectively). FTIR: C=O shifted from 1645 cm-1 to 1638 cm-1 and V=O, 980 cm-1. Electronic spectrum (DMSO): 598 nm, 810. Spectrophotometric titration: L/M, 2/1. Conductivity measurements, DMSO: 0.000 Ω-1mol-1cm2. The complex remained stable at least for 1h (conductivity, UV-vis measurements).