Catalytic studies of the dinuclear copper complex [Cu2(PTU-S-PTU)2] (PTU: Propylthiouracil) bioinspired in trisulfide bridges located in proteins.

CARO-RAMÍREZ J.; ROQUE-BORDA M.; MARTINI N.; PARENTE J.E.; URQUIZA, N.; PIRO, O. E.; GUSTAVO ETCHEVERRÍA; WILLIAMS P.A.M.; FERRER E.G

Montevideo

Encuentro; VII Latin American Meeting on Biological Inorganic Chemistry; 2021

Universidad de la República, Uruguay

Catalysis is an important area of chemistry that can solve future problems related to new materials for industry, medicine, and energy resources. Researchers have focused attention on biocatalysis, organocatalysis, or the use of metabolizable metal complexes [1]. Because of the restrictions on the use of natural or artificial metalloenzymes the so-called SIMCats (small-molecule intracellular metal catalysts) became a relevant topic in the integration of inorganic catalysts with living systems [2]. In connection with our previous work [2], we present the synthesis and characterization of a Cu(II)-dinuclear complex obtained by in situ transformations of the propylthiouracil (PTU) ligand formulated as [Cu2(PTU-S-PTU)2] (C28H36Cu2N8O4S6), as well as the simulation of peroxidase enzymes and their relationship with the antithyroid activity.