Copper(II) complexes of Methimazole, an anti Grave´s disease drug. Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor.

URQUIZA, N.; MANCA, S. G.; MARÍA ALEJANDRA MOYANO; RAQUEL ARRIETA DELLMANS; LUIS LEZAMA; ROJO, T.; L. NASO; P. A. M. WILLIAMS; E. G. FERRER

BIOMETALS

SPRINGER

Año: 2010 vol. 23 p. 255 - 264

0966-0844

Methimazole (MeimzH) is an anti-thyroid drug and the first choice for patients with Grave’s disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)2(NO3)2].0.5H2O and [Cu(MeimzH)2(H2O)2](NO3)20.5H2O were synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis and UV-vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is known that copper(II) cation can act as an inhibitor of alkaline/phosphatase (ALP), the inhibitory effect of methimazole and its copper(II) complexes on ALP activity has also been investigated.