Computational studies, antimicrobial activity, inhibition of biofilm production, and safety profile of the cadmium complex of 1,10-phenanthroline and cyanoguanidine

D.B. FALKIEVICH; J.J. MARTÍNEZ MEDINA; W.S. ALEGRE; LEONOR L. LOPEZ TEVEZ; C.A. FRANCA; E.G. FERRER; P.A.M. WILLIAMS

APPLIED ORGANOMETALLIC CHEMISTRY

JOHN WILEY & SONS LTD

Lugar: LOndres; Año: 2022 vol. e669 p. 2 - 14

0268-2605

We have previously determined the crystal structure of the metal complex [Cd(1,10-phenanthroline)2(SO4)H2O]cyanoguanidine?5H2O that was characterized by spectroscopic measurements. The antibacterial activity was also determined by the agar diffusion test (zones of inhibition). In the present work, calculations based on density functional theory were performed to determine the contributions of the two different tautomers of cyanoguanidine to the vibrational IR and Raman experimental spectra. Moreover, the antimicrobial (antibacterial and antifungal) activity of the complex and cadmium ion was assessed and the minimum inhibitory concentration (MIC) was determined. The complexation increased the antimicrobial activity against Pseudomonas and behaved as a non-mutagenic and non-toxic compound. Therefore, the interaction of cadmium (II) with N and O-containing ligands may provide a promising strategy for the development of novel l and safe drugs with antimicrobial activity.