INVESTIGADORES
FAINBOIM Leonardo
artículos
Título:
Cytokines and Chronic Liver Diseases
Autor/es:
FAINBOIM L., CHERÑAVSKY A., PALADINO N., FLORES A C., ARRUVITO L.
Revista:
CYTOKINE & GROWTH FACTOR REVIEWS
Editorial:
ELSEVIER SCI LTD
Referencias:
Año: 2007 vol. 18 p. 143 - 157
ISSN:
1359-6101
Resumen:
From an immunological point of view, the healthy liver has been usually associated with the phenomenon of tolerance. A microenvironment of regulatory cytokines produced by liver Kuppfer cells and liver sinusoidal endothelial cells has contributed, together with resident dendritic cells, to generate a tolerogenic environment in this tissue. In this review we discussed the intrahepatic responses to different sorts of liver injury, such as hepatotrophic viruses, alcohol or putative self-antigens. In each case we analyzed the impact of different cytokines in the clinical outcome of the different pathological situations.