INVESTIGADORES
FAINBOIM Leonardo
artículos
Título:
Gender susceptibility to chronic hepatitis C virus infection associated with Interleukin-10 promoter polymorphism.
Autor/es:
N, FAINBOIM H, THEILER G, SCHRODER T, MUÑOZ AE, FLORES A C, GALDAME O, FAINBOIM L
Revista:
JOURNAL OF VIROLOGY
Editorial:
American Society for Microbiology
Referencias:
Año: 2006 vol. 80 p. 9144 - 9150
ISSN:
0022-538X
Resumen:
&lt;!-- /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";} @page Section1 {size:612.0pt 792.0pt; margin:70.85pt 3.0cm 70.85pt 3.0cm; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --&gt; <!-- /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";} @page Section1 {size:612.0pt 792.0pt; margin:70.85pt 3.0cm 70.85pt 3.0cm; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> Elevated levels of IL-10 were described in Hepatitis C virus (HCV) chronically infected patients. Thus, we investigated by SSOP technique the single-nucleotide polymorphisms of IL-10 promoter at positions –1082(G/A), -819(C/T) and –592(C/A) responsible for the haplotypes GCC, ACC and ATA associated with high, medium and low production of IL-10. We found an increase of the GCC/GCC genotype in this population (p=0.03, OR=1.9). HCV infected patients showed an elevated male:female ratio. However, when compared with healthy controls (HC) only female showed the increased frequency of the GCC/GCC genotype (p=0.0096, OR=2.5). Excluding from the analysis those women being HCV RNA negative, GCC/GCC became more significant (p=0.003, OR=3). This association resulted even stronger if we compared HC only with those RNA+ women with elevated alanine aminotransferase (ALT) levels (p=0.0003, OR=4.2). Conversely, in women patients with normal ALT levels, we found an increased frequency of the ACC/ACC genotype (p=0.047 OR=0.38) indicative of a protective effect. We found no relationship between the inflammatory activity index and the fibrosis stage with the IL-10 promoter polymorphism, because the GCC/GCC frequency was increased both in women with high or low levels of these parameters. Finally, only women patients with no response to IFN-a treatment showed a higher frequency of the GCC/GCC genotype (p=0.029, OR=4.7). In conclusion, a higher risk of an inefficient clearance of HCV and of developing a chronic HCV infection is present in women carrying the GCC/GCC haplotype.